A zettel-style static Web site is quite possible in Tinderbox.
David Kolb’s SPRAWLING PLACES project is perhaps the most sophisticated and best known exemplar. He wrote a prize-winning hypertext paper about the project, which involved a book and a Web hypertext: http://www.dkolb.org/twin.media.ht04/covershe.html
George P. Landow’s massive, sprawling Victorian Web deserves careful study. Begun in the mid-1980s, its style differs from Zettelkasten but is not incompatible with it. It might be your best exemplar. See also McGann’s Rosetti Archive and Crane’s Perseus. I’m less familiar with ToposText but it’s exciting and its progenitor, Brady Kiesling, is the real deal.
Howard Oakley has done a number of very thoughtful art-historical essays in Storyspace which resemble what you have in mind — most notably a study of Ovid in painting and sculpture. https://eclecticlight.co