You could make your Python server respond to HTTP URLs, and then create a TB note with
$URL set and
$AutoFetch to true. Then Tinderbox would periodically fetch the new content from your Python server and update the note.
Another possibility is using
runCommand to run a command-line utility (that might be during export only, I'm not sure).
I don't think there's a way to tell Tinderbox about updates... TB is going to have to pull.
If I were doing this, I'd expose URLs from the Python server and use Tinderbox's URL-fetching functionality to update the note content.